Epidemiological And Histopathologic Study Of Rhabdomyosarcoma cases in a tertiary Care hospital of Peshawar

Epidemiological and Histopathologic Study of Rhabdomyosarcoma Cases


  • Mohammad Manzoor Pathology Department, Bacha Khan Medical College, Mardan
  • Bismah Ahmad Registrar Oral Pathology, CMH Lahore Medical College and Institute of Dentistry, Lahore
  • Adnan Sarwar Department of Pathology, Pak International Medical College, Peshawar
  • Mohibullah Khan Department of Histopathology, Pak International Medical College, Peshawar
  • Inam-u llah Department of Food Science, The University of Haripur, KPK, Pakistan
  • Hina Mir Department of Biochemistry, Shaheed Benazir Bhutto Women University, Peshawar
  • Muhammad Awais Department of Clinical Sciences, College of Veterinary and Animal Sciences, Jhang
  • Sudhair Abbas Bangash Faculty of Life Science, Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar
  • Fares Muthanna Department of Pharmaceutical Care, School of Pharmacy, Walailak University, Nakhon Si Thammarat, 80160, Thailand




embryonal type, alveolar type, Peshawar, pleomorphic type – epidemiology, Rhabdomyosarcoma



Aim: This study aimed to find out rhabdomyosarcoma’s (RMS) histopathological and immunohistochemical features. Settings: The current study was carried out at the Department of Pathology, Section of Histopathology, Khyber Teaching Hospital Peshawar. The study duration was between from 1st January 2015 to 30th of December 2020. Results: In the current study, all the 300 occurrences were found to be relevant. The most prevalent rhabdomyosarcoma was embryonal rhabdomyosarcoma (ERMS) (87.4%), followed by alveolar rhabdomyosarcoma (ARMS) (9.4%). In the current study we found that embryonal rhabdomyosarcomas was most frequent in males (64%). ERMS were 16.1 percent found in the genitourinary system followed by neck and head region (46.7%). Most samples displayed positive Desmin and MyoD1 immunohistochemistry staining. Conclusions: It is consistent with previously published rhabdomyosarcoma data from all across the globe that our patients' epidemiologic information and microscopic findings are consistent with one other.



Arndt, C. A., Stoner, J. A., Hawkins, D. S., Rodeberg, D. A., Hayes-Jordan, A. A., Paidas, C. N., . . . Breneman, J. C. J. J. o. C. O. (2009). Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: children's oncology group study D9803. 27(31), 5182.


Caillaud, J., Gerard‐Marchant, R., Marsden, H., Unnik, A. V., Rodary, C., Rey, A., . . . oncology, p. (1989). Histopathological classification of childhood rhabdomyosarcoma: a report from the International Society of Pediatric Oncology pathology panel. 17(5‐6), 391-400.


Cavazzana, A., Schmidt, D., Ninfo, V., Harms, D., Tollot, M., Carli, M., . . . Salviati, G. J. T. A. j. o. s. p. (1992). Spindle cell rhabdomyosarcoma. A prognostically favorable variant of rhabdomyosarcoma. 16(3), 229-235. https://doi.org/10.1097/00000478-199203000-00002

Cessna, M. H., Zhou, H., Perkins, S. L., Tripp, S. R., Layfield, L., Daines, C., & Coffin, C. M. J. T. A. j. o. s. p. (2001). Are myogenin and myoD1 expression specific for rhabdomyosarcoma?: A study of 150 cases, with emphasis on spindle cell mimics. 25(9), 1150-1157.


Chiles, M. C., Parham, D. M., Qualman, S. J., Teot, L. A., Bridge, J. A., Ullrich, F., . . . Pathology, D. (2004). Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group. 7(6), 583-594. https://doi.org/10.1007/s10024-004-5058-x

Fletcher, C., Bridge, J., & Hogendoorn, P. (2013). F Mertens: WHO Classification of Tumours of Soft Tissue and Bone. In: Edition.

Gurney, J. G., Davis, S., Severson, R. K., Fang, J. Y., Ross, J. A., & Robison, L. L. J. C. I. I. J. o. t. A. C. S. (1996). Trends in cancer incidence among children in the US. 78(3), 532-541. https://doi.org/10.1002/(SICI)1097-0142(19960801)78:3<532::AID-CNCR22>3.0.CO;2-Z

Gurney, J. G., Ross, J. A., Wall, D. A., Bleyer, W. A., Severson, R. K., & Robison, L. L. J. J. o. p. h. o. (1997). Infant cancer in the US: histology-specific incidence and trends, 1973 to 1992. 19(5), 428-432. https://doi.org/10.1097/00043426-199709000-00004

Harms, D. (1995). Alveolar rhabdomyosarcoma: a prognostically unfavorable rhabdomyosarcoma type and its necessary distinction from embryonal rhabdomyosarcoma. In Soft tissue tumors (pp. 273-296): Springer. https://doi.org/10.1007/978-3-642-77289-4_14

Islam, K. D., Mahammad, N., Alam, S., Munmun, U. H. D., & Ruhul, M. J. P. N. J. o. B. (2020). Rhabdomyosarcoma in children: 17 years experiences in the department of paediatric surgery in BSMMU. 16.

Jo, V. Y., Mariño-Enríquez, A., & Fletcher, C. D. J. T. A. j. o. s. p. (2011). Epithelioid rhabdomyosarcoma: clinicopathologic analysis of 16 cases of a morphologically distinct variant of rhabdomyosarcoma. 35(10), 1523-1530. https://doi.org/10.1097/PAS.0b013e31822e0907

Molenaar, W., Oosterhuis, J., Oosterhuis, A., & Ramaekers, F. J. H. p. (1985). Mesenchymal and muscle-specific intermediate filaments (vimentin and desmin) in relation to differentiation in childhood rhabdomyosarcomas. 16(8), 838-843. https://doi.org/10.1016/S0046-8177(85)80256-2

Newton Jr, W. A., Gehan, E. A., Webber, B. L., Marsden, H. B., Van Unnik, A., Hamoudi, A. B., . . . Schmidt, D. J. C. (1995). Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study. 76(6), 1073-1085. https://doi.org/10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L

Ognjanovic, S., Linabery, A. M., Charbonneau, B., & Ross, J. A. J. C. I. I. J. o. t. A. C. S. (2009). Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975‐2005. 115(18), 4218-4226. https://doi.org/10.1002/cncr.24465

Parkin, D. M., Stiller, C. A., Draper, G. J., & Bieber, C. J. I. J. o. C. (1988). The international incidence of childhood cancer. 42(4), 511-520.


Raney, R. B., Walterhouse, D. O., Meza, J. L., Andrassy, R. J., Breneman, J. C., Crist, W. M., . . . Anderson, J. R. J. J. o. C. O. (2011). Results of the Intergroup Rhabdomyosarcoma Study Group D9602 protocol, using vincristine and dactinomycin with or without cyclophosphamide and radiation therapy, for newly diagnosed patients with low-risk embryonal rhabdomyosarcoma: a report from the Soft Tissue Sarcoma Committee of the Children's Oncology Group. 29(10), 1312. https://doi.org/10.1200/JCO.2010.30.4469

Stock, N., Chibon, F., Binh, M. B. N., Terrier, P., Michels, J. J., Valo, I., . . . Decouvelaere, A.-V. J. T. A. j. o. s. p. (2009). Adult-type rhabdomyosarcoma: analysis of 57 cases with clinicopathologic description, identification of 3 morphologic patterns and prognosis. 33(12), 1850-1859. https://doi.org/10.1097/PAS.0b013e3181be6209

Yasuda, T., Perry, K. D., Nelson, M., Bui, M. M., Nasir, A., Goldschmidt, R., . . . Bridge, J. A. J. H. p. (2009). Alveolar rhabdomyosarcoma of the head and neck region in older adults: genetic characterization and a review of the literature. 40(3), 341-348. https://doi.org/10.1016/j.humpath.2008.08.006



DOI: 10.54393/pbmj.v4i2.253
Published: 2021-12-29

How to Cite

Manzoor, M., Ahmad, B., Sarwar, A., Khan, M., llah, I.- u, Mir, H., Awais, M. ., Bangash, S. A., & Muthanna, F. (2021). Epidemiological And Histopathologic Study Of Rhabdomyosarcoma cases in a tertiary Care hospital of Peshawar: Epidemiological and Histopathologic Study of Rhabdomyosarcoma Cases. Pakistan BioMedical Journal, 4(2), 292–296. https://doi.org/10.54393/pbmj.v4i2.253



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