Bacteriological Profile and Drug Resistance Pattern of Isolates of ICU Patients In Hospital Of Peshawar

Bacteriological Profile and Drug Resistance Pattern

Authors

  • Muhammad Nabi Institute of Pharmaceutical Sciences, Khyber Medical University,(IPS-KMU), Peshawar, Pakistan
  • Shah Zaman Department of Pharmacology, Peshawar Medical and Dental College, Peshawar, Pakistan
  • Amna Umar Department of Pharmacology, Peshawar Medical and Dental College, Peshawar, Pakistan
  • Erum Rehman Department of Pharmacology, Peshawar Medical and Dental College, Peshawar, Pakistan
  • Zakia Subhan Department of Pharmacology, Khyber Medical University Institute of Medical Sciences (KMU-IMS), Kohat, Pakistan
  • Nighat Aziz Department of Pharmacology, Gomal Medical College, Medical Teaching Institute, Dera Ismail Khan, Pakistan
  • Nabiha Naeem Department of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, Pakistan
  • Ambreen Anjum Department of Psychology, Virtual University of Pakistan
  • Irfan Ullah Department of Life Sciences, School of Science, University of Management and Technology (UMT), Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i6.603

Keywords:

Multidrug-resistant, infectious diseases, morbidity, death, intensive care units

Abstract

Multidrug-resistant infectious diseases are one of the top causes of death and morbidity among hospitalized patients worldwide. Objective: This study’s aim was to assess the frequency of common bacterial pathogens, as well as their antibiotic sensitivity & resistance, in various Intensive care unit tertiary care hospitals. Methods: The current investigation was conducted from February to May 2021 in multiple ICU at a primary care hospital in Peshawar. Patients who were admitted to any of the hospital's four intensive care units (ICUs) and patients medically speculated of having an infection within 48 hours of arrival were included. Patients' laboratory samples were selected based on clinical suspicion. Antibiotic sensitivity testing was performed on the samples. Result: E. coli 33(26) was the most commonly isolated bacteria across all samples. “In NICU, CONS 17(67.78), in 7(28.28), in MICU, PICU E. coli, E. coli, Pseudomonas spp and Acinetobacter spp.11(22.39), and in E. coli, SICU 17(46.82) were predominantly isolated” “Amikacin 29(88.6), Cefuroxime 21(65), Klebsiella sp. to Cefoperazone+Salbactum 15(79), Pseudomonas to Tazobactum+Piperacillin 12(66), and Acinetobacter sp. to Sulbactum+Cefoperazone 12(66) are commonly used antibiotics against E. coli 12(56)”. Citrobacter spp. (67.8) was observed more followed by Proteus spp. (34.4) and Enterococcus (34.4). Conclusion: In the ICUs, infectious diseases and antimicrobial resistance are key barriers to patient outcome multidrug-resistant as well as expenditure. All intensive care units throughout the world face the issue of lowering the same.

References

Eskander HG, Morsy WYM, Elfeky Haajp. Intensive care nurses’ knowledge & practices regarding infection control standard precautions at a selected Egyptian cancer hospital. Prevention. 2013;4(19):160-74.

Eggimann P, Pittet D. Infection control in the ICU. Chest. 2001 Dec;120(6):2059-93. doi: 10.1378/chest.120.6.2059.

Kumhar GD, Ramachandran VG, Gupta P. Bacteriological analysis of blood culture isolates from neonates in a tertiary care hospital in India. Journal of Health, Population and Nutrition. 2002 Dec 1:343-7.

Abbas SH, Naeem M, Adil M, Naz SM, Khan A, Khan Mujjoamca. Sensitivity patterns of Pseudomonas aeruginosa isolates obtained from clinical specimens in Peshawar. Journal of Ayub Medical College Abbottabad. 2015 Jun;27(2):329-32.

Hecini-Hannachi A, Bentchouala C, Lezzar A, Laouar H, Benlabed K, Smati FJAJoMR. Multidrug-resistant bacteria isolated from patients hospitalized in Intensive Care Unit in University Hospital of Constantine, Algeria (2011-2015). African Journal of Microbiology Research. 2016 Sep; 10(33):1328-36. doi.org/10.5897/AJMR2016.8257

Ullah O, Khan A, Ambreen A, Ahmad I, Akhtar T, Gandapor AJ, et al. Antibiotic sensitivity pattern of bacterial isolates of neonatal septicemia in Peshawar, Pakistan. Archives of Iranian medicine. 2016 Dec; 19(12):0.

Nasim O, Rustam Z, Mufarrih Smjjormi. Bacteriological profile and antimicrobial susceptibility pattern of sputum samples in patients presenting to the pulmonology ward of a tertiary care hospital of Peshawar. Journal of Rehman Medical Institute. 2018; 4(2):16-9.

Rafiq MS, Rafiq MI, Khan T, Rafiq M, Khan MM. Effectiveness of simple control measures on methicillin-resistant Staphylococcus aureus infection status and characteristics with susceptibility patterns in a teaching hospital in Peshawar. Journal of Pakistan Medical Association. 2015 Sep; 65(9):915-20.

Abbas S, Sabir AU, Khalid N, Sabir S, Khalid S, Haseeb S, et al. Frequency of Extensively Drug-Resistant Gram-Negative Pathogens in a Tertiary Care Hospital in Pakistan. Cureus. 2020 Dec; 12(12): e11914. doi: 10.7759/cureus.11914.

Ahmed W. Microorganisms related with ventilator Associated pneumonia (VAP) and their antibiotic sensitivity pattern. Journal of Rawalpindi Medical College. 2014 Jun ; 18(1):45-8.

Ahmed A, Lutfi S, Al-Hail M, Al-Saadi Mjajpcr. Antibiotic susceptibility patterns of microbial isolates from blood culture in the neonatal intensive care unit of Hamad Medical Corporation (HMC), Doha, Qatar. Asian Journal of Pharmacutical and Clinical Research. 2013;(6):191-5.

Pattanayak C, Patanaik SK, Datta PP, Panda P. Assessment of Antibiotic Sensitivity Pattern of Bacterial Isolates in the Intensive Care Unit of a Tertiary Care Hospital in Eastern India. Issues and Developments in Medicine and Medical Research. 2022 Feb; 10:71-81. doi.org/10.9734/bpi/idmmr/v10/2590C

Saxena S, Priyadarshi M, Saxena A, Singh R. Antimicrobial consumption and bacterial resistance pattern in patients admitted in I.C.U at a tertiary care center. Journal of infection and public health. 2019 Sep; 12(5):695-699. doi: 10.1016/j.jiph.2019.03.014.

Setu SK, Sattar Anijejob. Antimicrobial Resistant Profile of Bacterial Isolates in The Intensive Care Unit of a Tertiary Care Hospital in Bangladesh. European Journal of Biomedical. 2021;8(2):06-12.

Ennab R, Al-Momani W, Al-Titi R, Elayan A. Antibiotic Profile of Pathogenic Bacteria Isolated from Postsurgical Site Infections in Public Hospitals in Northern Jordan. Infection and Drug Resistance.2022 Feb 2; 15:359-366. doi: 10.2147/IDR.S350406.

Loftus RW, Dexter F, Robinson ADM. High-risk Staphylococcus aureus transmission in the operating room: A call for widespread improvements in perioperative hand hygiene and patient decolonization practices. American Journal of Infection Control. 2018 Oct; 46(10):1134-1141. doi: 10.1016/j.ajic.2018.04.211.

Vermeil T, Peters A, Kilpatrick C, Pires D, Allegranzi B, Pittet D. Hand hygiene in hospitals: anatomy of a revolution. Journal of Hospital Infection. 2019 Apr; 101(4):383-392. doi: 10.1016/j.jhin.2018.09.003.

Organization WH. Core competencies for infection prevention and control professionals. 2020.

Choe PG, Lim J, Kim EJ, Kim JH, Shin MJ, et al. Impact of national policy on hand hygiene promotion activities in hospitals in Korea. Antimicrobial Resistance & Infection Control. 2020 Sep; 9(1):157. doi: 10.1186/s13756-020-00817-3.

Zingg W, Storr J, Park BJ, Ahmad R, Tarrant C, Castro-Sanchez E, et al. Geneva IPC-Think Tank. Implementation research for the prevention of antimicrobial resistance and healthcare-associated infections; 2017 Geneva infection prevention and control (IPC)-think tank (part 1). Antimicrobial Resistance & Infection Control. 2019 May; 8:87. doi: 10.1186/s13756-019-0527-1.

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Published

2022-06-30
CITATION
DOI: 10.54393/pbmj.v5i6.603
Published: 2022-06-30

How to Cite

Nabi, M. ., Zaman, S. ., Umar, A. ., Rehman, E. ., Subhan, Z. ., Aziz, N. ., Naeem, N. ., Anjum, A. ., & Ullah, I. (2022). Bacteriological Profile and Drug Resistance Pattern of Isolates of ICU Patients In Hospital Of Peshawar: Bacteriological Profile and Drug Resistance Pattern. Pakistan BioMedical Journal, 5(6), 281–285. https://doi.org/10.54393/pbmj.v5i6.603

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