Histology of Placenta in Normotensive and Hypertensive Cases in Khyber Pakhtunkhwa: A Comparative Study

Histology of Placenta in Normotensive and Hypertensive Cases

Authors

  • Zahid Sarfaraz Khan Anatomy Department, KGMC, Khyber Pakhtoonkhwa
  • Farooq Khan Anatomy Department, Peshawar Medical College, Peshawar
  • Asma Amir Anatomy Department, Peshawar Medical College, Peshawar
  • Fatima Daud Anatomy Department, Pak International Medical College, Peshawar
  • Muhammad Ataullah Department of Anatomy, Khyber Girls Medical College, Hayatabad Peshawar
  • Muhammad Ateeq Institute of Biological Sciences, Sarhad University of Science & Information Technology, Peshawar, Pakistan
  • Irfan Ullah Department of Life Sciences, School of Science, University of Management and Technology (UMT)

DOI:

https://doi.org/10.54393/pbmj.v5i4.387

Keywords:

Morbid alterations, hypertensive, normotensive, women's, placentas

Abstract

One of the most common pregnancy complications is Hypertension. It has a major effect on maternal and neonatal morbidities and fatalities. The placenta is an important organ for the maintenance of pregnancy and the nourishment of the fetus.  Objective: To compare the morbid variations in the placenta of hypertensive and normotensive mothers. Methods: From the obstetrics and gynecology department, a hundred placentae of hypertension and normotensive females were collected. The placentae were preserved in formalin and sectioned. Blocks prepared were stained with hematoxylin and eosin. Results: The placentae from 50 normotensive mothers with 26±3.1 years (mean age) and 50 hypertensive mothers with 26± 2 years (mean age). In normotensive patients 12% Infarction was seen and 70% of severe hypertensive patients while syncytial knots were found in 70% of cases of severe hypertension, while calcification was observed in 90%. In severe hypertension, stroma fibrosis and hypervascularity increase in proportion to the degree of hypertension, with 50% and 30% cases seen in severe hypertension, respectively. Conclusions: In pregnancy hypertension causes, Stromal fibrosis syncytial knots, calcified, hypervascularity, all of which impair the uteroplacental flow of blood and lower newborn weight.

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Published

2022-04-30

How to Cite

Sarfaraz Khan, Z. ., Khan, F. ., Amir, A. ., Daud, F., Ataullah, M., Ateeq, M. ., & Ullah, I. . (2022). Histology of Placenta in Normotensive and Hypertensive Cases in Khyber Pakhtunkhwa: A Comparative Study : Histology of Placenta in Normotensive and Hypertensive Cases. Pakistan BioMedical Journal, 5(4), 218–221. https://doi.org/10.54393/pbmj.v5i4.387

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