An Assessment of Biochemical biomarkers alterations in COVID-19 patients: Biochemical Biomarkers Alterations in COVID-19 Patients

Shehla  Javaid; Miss Maham; Khizar  Abbas; Hafiz Muhammad Rehman; Sumaira  Kousar; Fareeha  Bashir; Sidra  Gul; Rahat  jamil

doi:10.54393/pbmj.v5i1.321

Authors

Shehla Javaid University Institute of Medical Lab Technology, University Of Lahore, Lahore Pakistan
Miss Maham University Institute of Medical Lab Technology, University Of Lahore, Lahore Pakistan
Khizar Abbas University Institute of Medical Lab Technology, University Of Lahore, Lahore Pakistan.
Hafiz Muhammad Rehman University Institute of Medical Lab Technology, University Of Lahore, Lahore Pakistan
Sumaira Kousar University Institute of Medical Lab Technology, University Of Lahore, Lahore Pakistan.
Fareeha Bashir University Institute of Medical Lab Technology, University Of Lahore, Lahore Pakistan
Sidra Gul University Institute of Medical Lab Technology, University Of Lahore, Lahore Pakistan
Rahat jamil Forman Christian College, University.

DOI:

https://doi.org/10.54393/pbmj.v5i1.321

Keywords:

COVID-19, biochemical markers, parameters, C reactive protein, ferritin, metabolic alteration

Abstract

COVID-19 (coronavirus disorder 2019) is a sickness as a result of a virulent virus named SARS-CoV-2 and turned into discovered in December 2019 in Wuhan, China. Objectives: To evaluate the most common biochemical parameters those are increased in COVID-19 positive patients and ultimately can be used as a diagnostic marker for the evaluation and staging of disease. Methods: This study included 200 COVID-positive patients confirmed with PCR. The clinical profile was recorded from various conventional laboratories. Data was analyzed statistically by applying sample t test to the data. Results: Total 200 patients were included in the study. Increased levels of various biochemical parameters have been found including ferritin, CRP and d- dimmer. D-dimer was elevated in 99.5 percent (n = 199) whereas 0.5 percent (n = 1) were normal and ferritin was elevated in 65.5 percent (n = 131) and was normal in 32.5 percent (n = 65). CRP was elevated in 81.5% (n=163) patients. Variations was also seen in Electrolytes like potassium was elevated in 53 % (n=106) and was low value in 8% (n= 16) while it remained normal in normal in 39% (n= 78). Sodium ions were high in 25.5% (n=51), reduced in 37.5% (n = 75) while 375 (n=74) were normal. Chloride was elevated in 32.5% reduced in 26% while it was normal in 41.5%. The metrics that remained normal were: urea (96.5%), creatinine (66.5%), total bilirubin (84%), platelets (86.5%), and TLC (73%). Ferritin, CRP and d-dimmer had a p value lower than 0.05 showing significant results. Conclusion: This study concluded that some parameters particularly d-dimer, ferritin, C reactive protein were considered to be predictive markers for the initial diagnose of COVID-19.

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