Preventative role of Selenium in Keshan Disease: A Review


  • Bahisht Rizwan University Institute of Diet and Nutritional Science, Department of Allied Health Sciences, The University of Lahore, Lahore, Pakistan.
  • Sammar Fatima University Institute of Diet and Nutritional Science, Department of Allied Health Sciences, The University of Lahore, Lahore, Pakistan.
  • Shahnai Basharat University Institute of Diet and Nutritional Science, Department of Allied Health Sciences, The University of Lahore, Lahore, Pakistan.
  • Mishal Liaqat University Institute of Diet and Nutritional Science, Department of Allied Health Sciences, The University of Lahore, Lahore, Pakistan
  • Maham Saeed University Institute of Diet and Nutritional Science, Department of Allied Health Sciences, The University of Lahore, Lahore, Pakistan.
  • Waniya Javed University Institute of Diet and Nutritional Science, Department of Allied Health Sciences, The University of Lahore, Lahore, Pakistan.



Selenium, Keshan disease, Cardiomyopathy, Selenium supplementation.


Mineral deficiencies have caused severe health consequences in developing countries. Among many other minerals, selenium is also an essential nutritional trace mineral element that is critical to the normal physiology of humans. In 1817, Swedish chemist and physician Jons Jacob Berzelius discovered this element. The US Department of Agriculture has an RDA of 55 μg/day for adults. Regional dietary deficiency of selenium caused Keshan and Kashin-Beck diseases. Keshan disease is endemic congestive cardiomyopathy, characterized by cardiac insufficiency, heart enlargement, arrhythmia, and electrocardiographic modifications. First identified in 1935 in Keshan County, Heilongjiang Province, northeast China. This disease is clinically divided into four categories: acute, subacute, chronic, and latent. However, selenium supplementations to the residents of Keshan disease endemic areas significantly reduced the incidence of KD. Thus, the government decided to apply sodium selenite to growing crops, and the incidence of the disease decreased dramatically.


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How to Cite

Rizwan, B. ., Fatima, S. ., Basharat, S. ., Liaqat, M. ., Saeed, M., & Javed, W. . (2021). Preventative role of Selenium in Keshan Disease: A Review. Pakistan BioMedical Journal, 4(2), 36–41.



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