Effect Of Topical Application of N-Acetyl Cysteine and Vascular Endothelial Growth Factor on Cutaneous Wound Healing: Topical NAC and VEGF in Wound Healing

Fatima Ali; Omer Sheraz; Muhammad Shahid Nadeem; Nadia Wajid

doi:10.54393/pbmj.v7i12.1313

Authors

Fatima Ali Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
Omer Sheraz Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan
Muhammad Shahid Nadeem Department of Biochemistry, King Abdulaziz University, Jeddah, Saudi Arabia
Nadia Wajid Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v7i12.1313

Keywords:

N-acetyl Cysteine, Vascular Endothelial Growth Factor, HCL Burn, Wound Healing

Abstract

Safety and effectiveness of topical N-acetyl cysteine (NAC) and vascular endothelial growth factor (VEGF) in the promotion of wound healing because of their in vivo anti-inflammatory and antioxidative effects. Objectives: To assess the effectiveness of topical NAC and VEGF, alone and combined, in accelerating burn wound healing. Methods: This randomized controlled laboratory pilot study used aseptic methods, two square skin burns were inflicted using HCl laterally on nine anaesthetized Sprague Dawley rats. The treatments, namely vaseline, vaseline and 3% NAC, VEGF (intradermal), and 3% NAC + VEGF, were topically administered separately. The wound healing process was determined by erythema, exudate, development of crust, swelling, as well as ulceration. Results: The 3% NAC + VEGF combination accelerated wound healing, visible through better and faster epithelization, while no significant difference in wound healing was observed with vaseline treatment alone as indicated by the histopathological results. Conclusions: In conclusion, the study highlighted the potential effectiveness of NAC and VEGF to overcome conditions associated with slow healing in chronic burns and to prevent secondary bacterial as well as fungal infections.

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