Evaluating the effect of Ginger Powder on Bilirubin, Creatinine, Urea and Uric Acid on Experimental Diabetic Wistar Rats in Randomized Control Trial

Effect of Ginger Powder on Bilirubin, Creatinine, Urea and Uric Acid on Experimental Diabetic Wistar Rats.

Authors

  • Maryam Maqsood University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Punjab-Pakistan
  • Saima Naaz Department of Clinical Nutrition, NUR International University, Lahore, Pakistan
  • Huma Bader Ul Ain University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Punjab-Pakistan
  • Zunaira Mushtaq Department of Human Nutrition and Dietetics, Riphah International University, Faisalabad, Pakistan
  • Makia Nasir College of Nutrition, Multan Medical Dental College, Multan, Pakistan
  • Aiza Qamar Department of Nutrition and Health Promotion, University of Home Economics, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v5i1.325

Keywords:

Diabetes, Ginger powder, Bilirubin, Creatinine, Urea, Uric Acid

Abstract

Today the world is dealing with rapidly increasing cases of diabetes mellitus especially type 2 diabetes which creates insulin resistance. Scientists are working with different nutraceuticals to cure this disease. Objective: Ginger plays an important role in different ailments such as cardiovascular diseases, hypertension, cancers, gastrointestinal functions, and diabetes mellitus. In the present study, ginger powder was analyzed for its anti-diabetic effect. The ginger powder was analyzed for its proximate composition. Methods: The bio-efficacy study was done on Alloxan-induced Wistar rats by feeding them ginger powder at three levels i.e. 1%, 3%, and 5% ginger powder for a period of 4 weeks. There were 4 groups (one was control and the other three getting different percentages of ginger powder), each containing 5 rats. The blood samples were collected at 0 days, 15th day, and 28th day. Blood sugar and insulin levels were measured. The data thus obtained was statistically analyzed to find out the level of significance. Results showed that glucose levels significantly decreased along with a significant increase in insulin levels. This research design concludes that ginger powder has positive effects in lowering blood sugar levels. Hence, the usage of ginger powder and ginger tea should be increased in diabetic patients to reduce hyperglycemia in diabetic patients and overcome high BSL levels in pre-diabetics. Conclusions: Results of this study concluded that in ginger powder 1.7 STD magnesium and 0.3 STD chromium are present. Moreover, this research study also declared that mean values of RFTs i.e. bilirubin, creatinine, urea, uric acid had a significant change in the G4 group as mean results of 0.591±0.032, 0.814±0.058, 0.814±0.058, 0.9508±0.051 respectively.

References

Hong K, Hong J, Chung H, Lee H, Lee H, et al., Monoclonal Gammopathy Associated Scleredema Adultorum of Buschke in a Patient with Diabetes Mellitus Successfully Treated with Intravenous Immunoglobulin and Narrow Band Ultraviolet B Phototherapy-Annals of Dermatology. 2021. 33(6):586. doi:10.5021/ad.2021.33.6.586.

Arablou T, Aryaeian N, Valizadeh M, Sharifi F, Hosseini A et al., The effect of Ginger Consumption on Glycemic Status Lipid Profile and Some Inflammatory Markers in Patients with Type 2 Diabetes Mellitus-International Journal of Food Sciences and Nutrition. 2014. 65(4):515. doi:10.3109/09637486.2014.880671.

Stoicescu M, Calniceanu H, Țig I, Nemeth S, Tent A et al., Romanul. Significant Aspects and Correlation between Glycemic Control and Generalized Chronic Periodontitis in Type 2 Diabetes Mellitus Patients-Experimental and Therapeutic Medicine. 2021. 22(1):1. doi:10.3892/etm.2021.10103.

Deeds M, Anderson J, Gastineau A, Hiddinga D et al., Kudva. Single dose streptozotocin induced diabetes considerations for study design in islet transplantation models- Journal of Laboratory animals. 2011. 45(3):131. doi:10.1258/la.2010.010090.

Ferrari C. Functional Foods Herbs and Nutraceuticals towards Biochemical Mechanisms of healthy aging-Bio gerontology. 2004. 5(5):275. doi: 10.3390/nu2060611.

Al Amin Z, Thomson M, Al Qattan K, Peltonen K, R. Shalaby and Ali M. Anti Diabetic and Hypolipidaemic Properties of Ginger (Zingiber officinale) in Streptozotocin Induced Diabetic Rats-British Journal of Nutrition. 2006. 96(4):660-666. doi: 10.1079/bjn20061849.

Chen Z, Peng C, Jiao R, Wong Y, Yang N et al.,Anti-Hypertensive Nutraceuticals and Functional Foods-Journal of agricultural and food chemistry. 2009. 57(11): 4485-4499 . doi.org/10.1021/jf900803r.

Labib M, Sargent E and Kelley SO. Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules-Chemical Reviews. 2016. 116(16):9001-9090. doi.org/10.1021/acs.chemrev.6b00220.

Afshari AT, Shirpoor A, Farshid A, Saadatian R, Rasmi Y et al.,The Effect of Ginger on Diabetic Nephropathy Plasma Antioxidant Capacity and Lipid Peroxidation in Rats-Food Chemistry. 2021. 101(1):148-153. doi:10.1016/j.foodchem.2006.01.013.

Al Hroob A, Abukhalil M, Alghonmeen D and Mahmoud AM. Ginger alleviates Hyperglycemia Induced Oxidative Stress Inflammation and Apoptosis and Protects Rats against Diabetic Nephropathy-Biomedicine & Pharmacotherapy. 2018. 106(381):389.doi: 10.1016/j.biopha.2018.06.148.

Horwitz W. Official Methods of Analysis of Association of Official Analytical Chemists International-AOAC Press Washington DC USA. 2006.4(18):3doi:https://academic.oup.com/jaoac/artile-acbstract/65/2/450/5702962.

Attari V, Mahluji S, Jafarabadi M and Ostadrahimi A. Effects of Supplementation with Ginger Zingiber officinale Roscoe on Serum Glucose Lipid Profile and Oxidative Stress in Obese Women A Randomized Placebo Controlled Clinical Trial-Journal of Pharmaceutical Sciences. 2015. 21(4):184-191. doi:10.15171/PS.2015.35.

Bhandari U, Kanojia R and Pillai KK. Effect of Ethanolic Extract of Zingiber officinale on Dyslipidaemia in Diabetic Rats-Journal of Ethnopharmacology. 2005. 97(2):227-230. doi.org/10.1016/j.jep.2004.11.011.

Devasagayam A, Tilak J, Boloor K, Sane S, Ghaskadbi S and Lele RD. Free Radicals and Antioxidants in Human Health Current Status and Future Prospects Enhanced Extraction of Oleoresin from Ginger Zingiber officinale Rhizome Powder Using Enzyme Assisted Three Phase Participation-Food Chem. 2017 27(36):216.doi:10.1016/j.foodchem.2016.07.180.

Ercan M, Bostanci B, Teke Z, Karaman K, Dalgic T et al.. Predictive Factors for Conversion to Open Surgery in Patients Undergoing Elective Laparoscopic Cholecystectomy-Journal of Laparoendoscopic and Advanced Surgical Techniques 2010. 20(5): 427. doi: 10.1089/lap.2009.0457.

Ghareib SA, El Bassossy M, Elberry A, Azhar A, Watson M et al., Protective Effect of Zingerone on Increased Vascular Contractility in Diabetic Rat Aorta. Eur. J. Pharm. 2016. 780(174)doi.org/10.1016/j.ejphar.2016.03.046.

Ilkhanizadeh B, Shirpoor A, Nemati S and Rasmi YE. Protective Effects of Ginger Zingiber officinale Extract Against Diabetes Induced Heart Abnormality in Rats-Diabetes & metabolism journal. 2016. 40(1):46. doi: 10.4093/dmj.2016.40.1.46.

Kumar GS and Jayaveera N. A Textbook of Pharmacognosy and Phytochemistry S. Chand Publishing. 2014. 3(59): 130 doi :0.5958/0975-4385.2018.00010.9.

Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T and Roth AE. A Long Term Three Dimensional Liver Co Culture System for Improved Prediction of Clinically Relevant Drug Induced Hepatotoxicity-Toxicology and applied pharmacology. 2013. 268(1):1-16. doi: 10.1016/j.taap.2013.01.012.

Jain HV. Screening of Juniperus Communis Linn. Oil for Anthelmintic, Wound Healing and Hepatoprotective Activities in Rats-Doctoral dissertation RGUHS. 2010. 16(1):142doi:10.1177/0748233712469995.

Downloads

Published

2022-01-31
CITATION
DOI: 10.54393/pbmj.v5i1.325
Published: 2022-01-31

How to Cite

Maqsood, M., Naaz, S., Bader Ul Ain, H. ., Mushtaq, Z. ., Nasir, M. ., & Qamar, A. . (2022). Evaluating the effect of Ginger Powder on Bilirubin, Creatinine, Urea and Uric Acid on Experimental Diabetic Wistar Rats in Randomized Control Trial : Effect of Ginger Powder on Bilirubin, Creatinine, Urea and Uric Acid on Experimental Diabetic Wistar Rats. Pakistan BioMedical Journal, 5(1), 351–355. https://doi.org/10.54393/pbmj.v5i1.325

Issue

Section

Original Article

Plaudit

Most read articles by the same author(s)

<< < 1 2