Frequency of Hypothyroidism in Chronic Hepatitis C patients treated with Standard Interferon Therapy

Hypothroidism in HCV patients on Interferon Therapy

Authors

  • Muhammad Farooq Department of Medicine,District Headquarter Hospital, Hafizabad, Pakistan
  • Sami Ullah Mumtaz North Medical Ward, King Edward Medical University/ Mayo Hospital, Lahore, Pakistan
  • Hina Akhtar Department of Medicine, Aziz Bhatti Shaheed Teaching Hospital, Gujrat, Pakistan
  • Kanza Ashraf Department of Medicine,District Headquarter Hospital, Hafizabad, Pakistan
  • Tayyeba Komal Department of Pathology,Services Institute of Medical Sciences, Lahore, Pakistan
  • Irshad Hussain Qureshi East Medical Ward, King Edward Medical University/ Mayo Hospital, Lahore, Pakistan

DOI:

https://doi.org/10.52229/pbmj.v1i2.46

Abstract

Chronic hepatitis C is a major health problem associated with high mortality and morbidity. It is the most common chronic blood borne infection leading to chronic liver disease and hepatocellular carcinoma. One of the treatment used for hepatitis C is interferon therapy which can lead to thyroid dysfunction i.e. hyperthyroidism and hypothyroidism. OBJECTIVE: “To assess the frequency of hypothyroidism in chronic hepatitis C patients treated with standard interferon therapy”. METHODS:Thisdescriptive case series study was carried out at Outpatient Department of Medicine, King Edward Medical University/ Mayo Hospital Lahore for 06 months from July to December 2014.After ethical approval of the study, 200 patients of ages 15 to 65 years with both genders having chronic hepatitis C on Polymerase chain reaction (PCR)& normal thyroid functionstest were taken by Non-probability, purposive sampling technique. Informed written consent was taken from all the patients. Serum thyroid stimulating hormone level (TSH) was sent of all patients to Centre for Nuclear Medicine (CENUM), Mayo Hospital Lahore before and after the completion of three months of interferontherapy and hypothyroidism was considered as TSH>4.0 mIU/L (normal range: 0.2-4.0 mIU/L). RESULTS: The mean age of the patients was 36.29 + 8.5 years. Out of total 200 patients, 123 (61.5%) were male and 77 (38.5%) were female. At baselines mean TSH of the patients was 3.16 + 2.57 mIU/L. After 3 months of therapy 163 patients (81.5%) were euthyroid and 37 patients (18.5%) were having thyroid dysfunction. Among patients with thyroid dysfunction 29 (14.5% of total patients) were hypothyroid. Among hypothyroid patients, according to gender distribution 8 (27.6%) patients were male and 21 (72.4%) patients were female. The difference was statistically significant (P=0.0003). CONCLUSION: It is concluded from this study that there is significant frequency of hypothyroidism in patients of chronic hepatitis C treated with standard interferon therapy and females are at more risk of developing thyroid dysfunction particularly hypothyroidism after standard interferon therapy.

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Published

2018-12-31
CITATION
DOI: 10.52229/pbmj.v1i2.46
Published: 2018-12-31

How to Cite

Farooq, M., Mumtaz, S. U. ., Akhtar, . H. ., Ashraf, K. ., Komal, T. ., & Qureshi, . I. H. (2018). Frequency of Hypothyroidism in Chronic Hepatitis C patients treated with Standard Interferon Therapy: Hypothroidism in HCV patients on Interferon Therapy. Pakistan BioMedical Journal, 1(2). https://doi.org/10.52229/pbmj.v1i2.46

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