Histology of Placenta in Normotensive and Hypertensive Cases in Khyber Pakhtunkhwa: A Comparative Study

Histology of Placenta in Normotensive and Hypertensive Cases


  • Zahid Sarfaraz Khan Anatomy Department, KGMC, Khyber Pakhtoonkhwa
  • Farooq Khan Anatomy Department, Peshawar Medical College, Peshawar
  • Asma Amir Anatomy Department, Peshawar Medical College, Peshawar
  • Fatima Daud Anatomy Department, Pak International Medical College, Peshawar
  • Muhammad Ataullah Department of Anatomy, Khyber Girls Medical College, Hayatabad Peshawar
  • Muhammad Ateeq Institute of Biological Sciences, Sarhad University of Science & Information Technology, Peshawar, Pakistan
  • Irfan Ullah Department of Life Sciences, School of Science, University of Management and Technology (UMT)




Morbid alterations, hypertensive, normotensive, women's, placentas


One of the most common pregnancy complications is Hypertension. It has a major effect on maternal and neonatal morbidities and fatalities. The placenta is an important organ for the maintenance of pregnancy and the nourishment of the fetus.  Objective: To compare the morbid variations in the placenta of hypertensive and normotensive mothers. Methods: From the obstetrics and gynecology department, a hundred placentae of hypertension and normotensive females were collected. The placentae were preserved in formalin and sectioned. Blocks prepared were stained with hematoxylin and eosin. Results: The placentae from 50 normotensive mothers with 26±3.1 years (mean age) and 50 hypertensive mothers with 26± 2 years (mean age). In normotensive patients 12% Infarction was seen and 70% of severe hypertensive patients while syncytial knots were found in 70% of cases of severe hypertension, while calcification was observed in 90%. In severe hypertension, stroma fibrosis and hypervascularity increase in proportion to the degree of hypertension, with 50% and 30% cases seen in severe hypertension, respectively. Conclusions: In pregnancy hypertension causes, Stromal fibrosis syncytial knots, calcified, hypervascularity, all of which impair the uteroplacental flow of blood and lower newborn weight.


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DOI: 10.54393/pbmj.v5i4.387
Published: 2022-04-30

How to Cite

Sarfaraz Khan, Z. ., Khan, F. ., Amir, A. ., Daud, F., Ataullah, M., Ateeq, M. ., & Ullah, I. . (2022). Histology of Placenta in Normotensive and Hypertensive Cases in Khyber Pakhtunkhwa: A Comparative Study : Histology of Placenta in Normotensive and Hypertensive Cases. Pakistan BioMedical Journal, 5(4), 218–221. https://doi.org/10.54393/pbmj.v5i4.387



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