Assessment of Post-COVID-19 Complications in the Pakistani Population: A Detailed Survey into Late-Onset Adverse Events through Cross-Sectional Analysis

Post-COVID-19 Complications in the Pakistani Population: Late-Onset Adverse Events

Authors

  • Abo Ul Hassan Madni Department of Population Welfare, Government of Punjab, Jhelum, Pakistan
  • Noor Hassan Department of Chemistry, Government Graduate College, Lahore, Pakistan
  • Sajid Hameed Department of Public Health, Green International University, Lahore, Pakistan
  • Maryam Naeem Satti Pak Red Crescent Medical and Dental College, Lahore, Pakistan
  • Rana Hamad Ullah Pak Red Crescent Medical and Dental College, Lahore, Pakistan
  • Hafsa Adnan Department of Biological Sciences, National University of Medical Sciences, Rawalpindi, Pakistan
  • Muhammad Faisal Mushtaq Government Teaching Hospital, Lahore, Pakistan
  • Tallat Anwar Faridi University Institute of Public Health, The University of Lahore, Lahore, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v8i8.1299

Keywords:

Covid-19 Pandemic, Vaccination, Adverse Effects, Immunity

Abstract

COVID-19 was a health crisis that severely obstructed the healthcare system and public well-being. Although vaccination has been very instrumental in reducing mortality and morbidity due to COVID-19, concerns are still prevalent regarding its short- and long-term side effects. Objectives: To investigate the incidence and severity of the pandemic, which vary considerably across different demographic groups, especially in older age. Methods: The current descriptive exploratory study examines post-vaccination effects among various age and gender groups in Pakistan through an online survey of 220 individuals. Results: Nearly 24% of respondents have suffered from COVID-19 during the pandemic, with a high prevalence in older age. A vast majority, i.e., 92% were vaccinated for COVID-19. Results show that 47 percent of respondents have been affected by one or more kinds of post-vaccination effects. Segregating results, 28 percent faced neurological effects, 16% cardiovascular effects, 11% bleeding complications, 11% gastrointestinal effects, and 18% allergic reactions. Among female, 22% reported menstrual changes after receiving the vaccination for COVID-19. Two deaths were also reported among the respondents temporally following vaccination; however, the small number and the study design preclude any causal inference with multiple post-vaccination effects. Conclusions: Pre-existing health conditions, experiencing surgery, and growing age were significantly associated with a higher likelihood of reporting post-vaccination complications. This study plays an important part in tailoring future vaccination approaches and plans, eventually assisting Pakistan’s long-term public health preparedness.

References

World Health Organization (WHO). WHO Coronavirus (COVID-19) Dashboard [Internet]. Geneva: World Health Organization; 2024 [cited 2024 Jan 25]. Available from: https://covid19.who.int.

Verity R, Okell LC, Dorigatti I, Winskill P, Whittaker C, Imai N et al. Estimates of the Severity of Coronavirus Disease 2019: A Model-Based Analysis. The Lancet Infectious Diseases. 2020 Jun; 20(6): 669-77. doi: 10.1016/S1473-3099(20)30243-7. DOI: https://doi.org/10.1016/S1473-3099(20)30243-7

Peckham H, de Gruijter NM, Raine C, Radziszewska A, Ciurtin C, Wedderburn LR et al. Male Sex Identified by Global COVID-19 Meta-Analysis as A Risk Factor for Death and ITU Admission. Nature Communications. 2020 Dec; 11(1): 6317. doi: 10.1038/s41467-020-19741-6. DOI: https://doi.org/10.1038/s41467-020-19741-6

Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S et al. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. New England Journal of Medicine. 2020 Dec; 383(27): 2603-15. doi: 10.1056/NEJMoa2034577. DOI: https://doi.org/10.1056/NEJMoa2034577

Baden LR, El Sahly HM, Essink B, Kotloff K, Frey S, Novak R et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. New England Journal of Medicine. 2021 Feb; 384(5): 403-16. doi: 10.1056/NEJMoa2035389. DOI: https://doi.org/10.1056/NEJMoa2035389

Gee J. First Month of COVID-19 vaccine Safety Monitoring—United States, December 14, 2020–January 13, 2021. Morbidity and Mortality Weekly Report. 2021; 70(8): 283–288. doi: 10.15585/mmwr.mm7008e3. DOI: https://doi.org/10.15585/mmwr.mm7008e3

Frydrysiak-Brzozowska A, Haor B, Pluta A, Głowacka M. Population-Based Analysis of Vaccination Status and Post-Vaccination Adverse Events in Adults Aged 55 and Older. Journal of Clinical Medicine. 2025 Jun; 14(12): 4297. doi: 10.3390/jcm14124297. DOI: https://doi.org/10.3390/jcm14124297

Link-Gelles R. Interim Estimates of 2024–2025 COVID-19 Vaccine Effectiveness among Adults Aged ≥ 18 years—VISION and IVY Networks, September 2024–January 2025. Morbidity and Mortality Weekly Report. 2025; 74.

Chen CY and Su TC. Benefits and Harms of Covid-19 Vaccines in Cardiovascular Disease: A Comprehensive Review. Journal of Lipid and Atherosclerosis. 2023 May; 12(2): 119. doi: 10.12997/jla.2023.12.2.119. DOI: https://doi.org/10.12997/jla.2023.12.2.119

Petrilli CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y et al. Factors Associated with Hospitalization and Critical Illness Among 4,103 Patients with COVID-19 Disease in New York City. MedRxiv. 2020 Apr: 2020-04. doi: 10.1101/2020.04.08.20057794. DOI: https://doi.org/10.1101/2020.04.08.20057794

Patone M, Handunnetthi L, Saatci D, Pan J, Katikireddi SV, Razvi S et al. Neurological Complications After First Dose of COVID-19 Vaccines and SARS-CoV-2 Infection. Nature Medicine. 2021 Dec; 27(12): 2144-53. doi: 10.1038/s41591-021-01556-7. DOI: https://doi.org/10.1038/s41591-021-01556-7

Blumenthal KG, Robinson LB, Camargo CA, Shenoy ES, Banerji A, Landman AB et al. Acute Allergic Reactions to mRNA COVID-19 Vaccines. Journal of the American Medical Association. 2021 Apr; 325(15): 1562-5. doi: 10.1001/jama.2021.3976. DOI: https://doi.org/10.1001/jama.2021.3976

Menni C, Klaser K, May A, Polidori L, Capdevila J, Louca P et al. Vaccine Side-Effects and SARS-CoV-2 Infection After Vaccination in Users of the COVID Symptom Study App in the UK: A Prospective Observational Study. The Lancet Infectious Diseases. 2021 Jul; 21(7): 939-49. doi: 10.1016/S1473-3099(21)00224-3. DOI: https://doi.org/10.1016/S1473-3099(21)00224-3

Male V. Menstrual Changes After Covid-19 Vaccination. British Medical Journal. 2021 Sep; 374. doi: 10.1136/bmj.n2211. DOI: https://doi.org/10.1136/bmj.n2211

Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS et al. Post-Acute COVID-19 Syndrome. Nature Medicine. 2021 Apr; 27(4): 601-15. doi: 10.1038/s41591-021-01283-z. DOI: https://doi.org/10.1038/s41591-021-01283-z

Su Y, Yuan D, Chen DG, Ng RH, Wang K, Choi J et al. Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae. Cell. 2022 Mar; 185(5): 881-95.

Klein NP, Lewis N, Goddard K, Fireman B, Zerbo O, Hanson KE et al. Surveillance for Adverse Events After COVID-19 mRNA Vaccination. Journal of the American Medical Association. 2021 Oct; 326(14): 1390-9. doi: 10.1001/jama.2021.15072. DOI: https://doi.org/10.1001/jama.2021.15072

Barda N, Dagan N, Ben-Shlomo Y, Kepten E, Waxman J, Ohana R et al. Safety of the BNT162b2 mRNA COVID-19 Vaccine in a Nationwide Setting. New England Journal of Medicine. 2021 Sep; 385(12): 1078-90. doi: 10.1056/NEJMoa2110475. DOI: https://doi.org/10.1056/NEJMoa2110475

Greinacher A, Thiele T, Warkentin TE, Weisser K, Kyrle PA, Eichinger S. Thrombotic Thrombocytopenia After ChAdOx1 nCov-19 Vaccination. New England Journal of Medicine. 2021 Jun; 384(22): 2092-101. doi: 10.1056/NEJMoa2104840. DOI: https://doi.org/10.1056/NEJMoa2104840

Loo J, Spittle DA, Newnham M. COVID-19, Immunothrombosis and Venous Thromboembolism: Biological Mechanisms. Thorax. 2021 Apr; 76(4): 412-20. doi: 10.1136/thoraxjnl-2020-216243. DOI: https://doi.org/10.1136/thoraxjnl-2020-216243

World Health Organization. COVID-19 Vaccines: Safety Surveillance Manual. World Health Organization. 2020 Dec.

Edelman A, Boniface ER, Male V, Cameron ST, Benhar E, Han L et al. Association Between Menstrual Cycle Length And Covid-19 Vaccination: Global, Retrospective Cohort Study Of Prospectively Collected Data. British Medical Journal Medicine. 2022 Sep; 1(1): e000297. doi: 10.1136/bmjmed-2022-000297. DOI: https://doi.org/10.1136/bmjmed-2022-000297

Downloads

Published

2025-08-31
CITATION
DOI: 10.54393/pbmj.v8i8.1299
Published: 2025-08-31

How to Cite

Madni, A. U. H., Hassan, N., Hameed, S., Satti, M. N., Ullah, R. H., Adnan, H., Mushtaq, M. F., & Faridi, T. A. (2025). Assessment of Post-COVID-19 Complications in the Pakistani Population: A Detailed Survey into Late-Onset Adverse Events through Cross-Sectional Analysis: Post-COVID-19 Complications in the Pakistani Population: Late-Onset Adverse Events. Pakistan BioMedical Journal, 8(8), 34–42. https://doi.org/10.54393/pbmj.v8i8.1299

Issue

Section

Original Article

Plaudit

Most read articles by the same author(s)

1 2 3 > >>