A Comprehensive Review on Tinospora cordifolia Nutritional Profile, Phytochemistry, Pharmacology and Therapeutic Potential:  Tinospora cordifolia Nutritional Profile, Pharmacology and Therapeutic Potential

Muhammad Khalid Saeed; Naseem Zahra; Sehrish Rafique; Abdul Ahad Rasheed; Benish Rafique; Adnan Amjad

doi:10.54393/pbmj.v9i8.1384

Authors

Muhammad Khalid Saeed Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Lahore, Pakistan
Naseem Zahra Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Lahore, Pakistan
Sehrish Rafique Department of Food Science, University of the Punjab, Lahore, Pakistan
Abdul Ahad Rasheed Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Lahore, Pakistan
Benish Rafique Department of Food Safety and Quality Management, Bahauddin Zakariya University, Multan, Pakistan
Adnan Amjad Department of Human Nutrition, Bahauddin Zakariya University, Multan, Pakistan

DOI:

https://doi.org/10.54393/pbmj.v9i8.1384

Keywords:

Tinospora cordifolia, Nutritional Facts, Phytochemicals, Pharmacological Activities

Abstract

Medicinal herbs have been used since ancient times. Since synthetic drugs are expensive and have multiple side effects, the use of traditional medicine is the cheapest and most accessible way of treatment. The medicinal plant Tinospora cordifolia belongs to the Menispermaceae family. Immunomodulation, antipyretic action, antioxidant activity, anti-inflammatory action, liver protection, antidiabetic action, and antitumor activity are just a few of the many medicinal properties known about this plant. As a result of the presence of a high number of phytochemicals such as alkaloids, diterpenoid lactones, glycosides, steroids, and polysaccharides, T. cordifolia is an important constituent of modern herbal medicine. This review offers a comprehensive discussion of the phytochemistry, pharmacological properties, and ethnobotany of this medicinal plant. The literature was screened using predefined inclusion and exclusion criteria, and the extracted data were compiled in tabulated and figure form. Due to its adaptogenic properties and modification of the immune system, the plant has shown tremendous potential in being considered for medical research work, particularly in the treatment of infectious and chronic diseases. Its pharmacological properties have exhibited significant potential in increasing the usefulness of biopharmaceuticals in treating various diseases and industrial applications. This review brings out some important information concerning the nutritional information, phytochemicals, bioactive compounds, and pharmacological properties of Tinospora cordifolia for therapeutic uses. The researchers, physicians, pharmaceutical firms, and food industry can benefit a lot from the information since it will help them develop valuable drugs and food items.

References

Verma S. Phytopharmacological Profile of Tinospora cordifolia: An Updated Review. Journal of Pharmacognosy and Phytochemistry. 2026 Jan.

Siddiqui S, Jadaun S, Anusha R, Kumar N, Ashraf SA, Bishnoi JP. Medicinal Importance of Tinospora cordifolia (Willd.) Miers And Its Possible Use in the Food Industry for Value Addition. Discover Food. 2025 Oct; 5(1): 357. doi: 10.1007/s44187-025-00652-8. DOI: https://doi.org/10.1007/s44187-025-00652-8

Singh R and Sharma L. Potential role of Tinospora cordifolia in Management of COVID-19: A Systematic Review. International Journal of Health Sciences. 2022; 6(S5): 10597-608. doi: 10.53730/ijhs.v6nS5.10812. DOI: https://doi.org/10.53730/ijhs.v6nS5.10812

Ahsan R, Mishra A, Badar B, Owais M, Mishra V. Therapeutic Application, Phytoactives and Pharmacology of Tinospora cordifolia: An Evocative Review. Chinese Journal of Integrative Medicine. 2023 Jun; 29(6): 549-55. doi: 10.1007/s11655-023-3733-2. DOI: https://doi.org/10.1007/s11655-023-3733-2

Latif R and Nawaz T. Medicinal Plants and Human Health: A Comprehensive Review of Bioactive Compounds, Therapeutic Effects, and Applications. Phytochemistry Reviews. 2026 Mar; 25(3): 2299-342. doi: 10.1007/s11101-025-10194-7. DOI: https://doi.org/10.1007/s11101-025-10194-7

Yamini and Rana A. Bioactive Compounds and Medicinal Properties of Tinospora cordifolia. Biotechnology Innovations for a Sustainable Future: Integrating Clean Energy, Life on the Planet, Clean Water, and Climate Action. 2026 Jan: 807-28. doi: 10.1007/978-981-97-9859-9_39. DOI: https://doi.org/10.1007/978-981-97-9859-9_39

Shrestha J. Tinospora cordifolia (Willd.) Miers: Phytochemical Composition, Cytotoxicity, Proximate Analysis and Their Biological Activities. Cellular and Molecular Biology. 2021 Jan.

Patil VS and Malpathak NP. Micro-Morphoanatomical Approach for Comparative Analysis of Tinospora cordifolia (Willd.) Miers and Its Adulterant Plant Using SEM and Cryostat. 2017. doi: 10.5530/pj.2017.1.8. DOI: https://doi.org/10.5530/pj.2017.1.8

Anjum V, Bagale U, Kadi A, Potoroko I, Sonawane SH, Anjum A. Unveiling Various Facets of Tinospora cordifolia Stem in Food: Medicinal and Nutraceutical Aspects. Molecules. 2023 Oct; 28(20):7073. doi: 10.3390/molecules28207073. DOI: https://doi.org/10.3390/molecules28207073

Chowdhury P. In Silico Investigation of Phytoconstituents from Indian Medicinal Herb ‘Tinospora cordifolia (giloy)’ Against SARS-CoV-2 (COVID-19) by Molecular Dynamics Approach. Journal of Biomolecular Structure and Dynamics. 2021 Nov; 39(17): 6792-809. doi: 10.1080/07391102.2020.1803968. DOI: https://doi.org/10.1080/07391102.2020.1803968

Rizvi ZA, Babele P, Madan U, Sadhu S, Tripathy MR, Goswami S et al. Pharmacological Potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the Experimental Models of COVID-19, T Cell Differentiation, and Neutrophil Functions. Frontiers in Immunology. 2023 Mar; 14: 1138215. doi: 10.3389/fimmu.2023.1138215. DOI: https://doi.org/10.3389/fimmu.2023.1138215

Yates CR, Bruno EJ, Yates ME. Tinospora cordifolia: A Review of Its Immunomodulatory Properties. Journal of Dietary Supplements. 2022 Mar; 19(2): 271-85. doi: 10.1080/19390211.2021.1873214. DOI: https://doi.org/10.1080/19390211.2021.1873214

Philip S, Tom G, Balakrishnan Nair P, Sundaram S, Velikkakathu Vasumathy A. Tinospora cordifolia Chloroform Extract Inhibits LPS-Induced Inflammation via NF-κB Inactivation in THP-1cells and Improves Survival in Sepsis. BioMed Central Complementary Medicine and Therapies. 2021 Mar; 21(1): 97. doi: 10.1186/s12906-021-03244-y. DOI: https://doi.org/10.1186/s12906-021-03244-y

Nath H, Khataniar A, Bania KK, Mukerjee N, Al-Hussain SA, Zaki ME et al. Nano-Functionalization and Evaluation of Antimicrobial Activity of Tinospora cordifolia Against the TolB protein of Pseudomonas aeruginosa–An antibacterial and Computational Study. Frontiers in Microbiology. 2023 Apr; 14: 1138106. doi: 10.3389/fmicb.2023.1138106. DOI: https://doi.org/10.3389/fmicb.2023.1138106

Malabadi RB, Sadiya MR, Kolkar KP, Chalannavar RK, Baijnath H. Tinospora cordifolia (Amruthballi): Medicinal Plant with Anticancer activity. Magna Scientia Advanced Biology and Pharmacy. 2024 Mar; 11(02): 001-19. doi: 10.30574/msabp.2024.11.2.0017. DOI: https://doi.org/10.30574/msabp.2024.11.2.0017

Puri A and Patil S. Tinospora cordifolia Stem Extract-Mediated Green Synthesis of Selenium Nanoparticles and Its Biological Applications. Pharmacognosy Research. 2022; 14(3): 289-96. doi: 10.5530/pres.14.3.42. DOI: https://doi.org/10.5530/pres.14.3.42

Ali H and Dixit S. Extraction Optimization of Tinospora cordifolia and Assessment of the Anticancer Activity of Its Alkaloid Palmatine. The Scientific World Journal. 2013; 2013(1): 376216. doi: 10.1155/2013/376216. DOI: https://doi.org/10.1155/2013/376216

George G, Shyni GL, Mohan S, Abraham B, Nisha P, Ranjith S et al. In Vitro and in Vivo Anti-Inflammatory and Anti-Arthritic Effect of Tinospora cordifolia Via Modulation of JAK/STAT Pathway. Inflammopharmacology. 2023 Apr; 31(2): 1009-25. doi: 10.1007/s10787-023-01155-7. DOI: https://doi.org/10.1007/s10787-023-01155-7

Tiwari P, Nayak P, Prusty SK, Sahu PK. Phytochemistry and Pharmacology of Tinospora cordifolia: A Review. Systematic Reviews in Pharmacy. 2018; 9(1): 70-8. doi: 10.5530/srp.2018.1.14. DOI: https://doi.org/10.5530/srp.2018.1.14

Balkrishna A, Kumar A, Rohela A, Arya V, Gautam AK, Sharma H et al. Traditional Uses, Hepatoprotective Potential, and Phytopharmacology of Tinospora cordifolia: A Narrative Review. Journal of Pharmacy and Pharmacology. 2024 Mar; 76(3): 183-200. doi: 10.1093/jpp/rgae013. DOI: https://doi.org/10.1093/jpp/rgae013

Chaudhary A, Das R, Mehta K, Mehta DK. Indian Herb Tinospora cordifolia and Tinospora Species: Phytochemical and Therapeutic Application. Heliyon. 2024 May; 10(10). doi: 10.1016/j.heliyon.2024.e31229. DOI: https://doi.org/10.1016/j.heliyon.2024.e31229

Antul K, Amandeep P, Gurwinder S, Anuj C. Review on Pharmacological Profile of Medicinal Vine: Tinospora cordifolia. Current Journal of Applied Science and Technology. 2019 Jun; 35(5): 1-1. doi: 10.9734/cjast/2019/v35i530196. DOI: https://doi.org/10.9734/cjast/2019/v35i530196

Mishra A, Sharma K, Pandey J, Dev K, Kadan S, Sahai M et al. Tinosporaside from Tinospora cordifolia Encourages Skeletal Muscle Glucose Transport Through Both PI-3-Kinase- and AMPK-Dependent Mechanisms. Molecules. 2023 Jan; 28(2): 483. doi: 10.3390/molecules28020483. DOI: https://doi.org/10.3390/molecules28020483

Masilamani SD, Chokkalingam P, Hari R. Characterization, Cytotoxicity and Anti-Oxidant Studies of Phytoniosome Loaded with Ethanolic Leaf Extract of Tinospora cordifolia. Avicenna Journal of Medical Biotechnology. 2023 Jul; 15(3): 196. doi: 10.18502/ajmb.v15i3.12930. DOI: https://doi.org/10.18502/ajmb.v15i3.12930

Arunachalam K, Yang X, San TT. Tinospora cordifolia (Willd.) Miers: Protection Mechanisms and Strategies Against Oxidative Stress-Related Diseases. Journal of Ethnopharmacology. 2022 Jan; 283: 114540. doi: 10.1016/j.jep.2021.114540. DOI: https://doi.org/10.1016/j.jep.2021.114540

Mandar BK, Khanal P, Patil BM, Dey YN, Pasha I. In Silico Analysis of Phytoconstituents from Tinospora Cordifolia with Targets Related to Diabetes and Obesity. In Silico Pharmacology. 2021 Jan; 9(1)3. doi: 10.1007/s40203-020-00063-w. DOI: https://doi.org/10.1007/s40203-020-00063-w

Giannenas I, Sidiropoulou E, Bonos E, Christaki E, Florou-Paneri P. The History of Herbs, Medicinal and Aromatic Plants, and Their Extracts: Past, Current Situation and Future Perspectives. In Feed Additives. 2020 Jan: 1-18. doi: 10.1016/B978-0-12-814700-9.00001-7. DOI: https://doi.org/10.1016/B978-0-12-814700-9.00001-7

Birla H, Rai SN, Singh SS, Zahra W, Rawat A, Tiwari N et al. Tinospora cordifolia Suppresses Neuroinflammation in Parkinsonian Mouse Model. Neuromolecular Medicine. 2019 Mar; 21(1): 42-53. doi: 10.1007/s12017-018-08521-7. DOI: https://doi.org/10.1007/s12017-018-08521-7

Satruhan DK. A Review on Tinospora cordifolia: Biological and Medicinal Properties. Journal of Pharmaceutical Negative Results. 2022: 3929-40.

Sajith KS and Farhan H. Pharmacological Effects of Tinospora cordifolia (Giloy) in Human Body. The Pharma Innovation Journal. 2022; 11: 07-10.

Sharma U, Bala M, Kumar N, Singh B, Munshi RK, Bhalerao S. Immunomodulatory Active Compounds from Tinospora cordifolia. Journal of Ethnopharmacology. 2012 Jun; 141(3) :918-26. doi: 10.1016/j.jep.2012.03.027. DOI: https://doi.org/10.1016/j.jep.2012.03.027

Murshid GM, Kundu SK, Sohrab MH, Mazid MA. Pharmacological Overview of Tinospora cordifolia, an Ethnologically Important Plant of Bangladesh. Pharmacology and Pharmacy. 2022 Mar; 13: 93-106. doi: 10.4236/pp.2022.133007. DOI: https://doi.org/10.4236/pp.2022.133007

Chandrasekaran CV, Mathuram LN, Daivasigamani P, Bhatnagar U. Tinospora cordifolia, A Safety Evaluation. Toxicology in vitro. 2009 Oct; 23(7): 1220-6. doi: 10.1016/j.tiv.2009.07.030. DOI: https://doi.org/10.1016/j.tiv.2009.07.030

Payyappallimana U, Ravikumar K, Venkatasubramanian P. Can Guduchi (Tinospora cordifolia), A Well-Known Ayurvedic Hepato-Protectant, Cause Liver Damage? Journal of Ayurveda and Integrative Medicine. 2023 Jan; 14(1): 100658. doi: 10.1016/j.jaim.2022.100658. DOI: https://doi.org/10.1016/j.jaim.2022.100658

Ahmad S, Dubey SH, Tiwari AK, Prasad M. Pharmacological Review of Tinospora cordifolia: A Traditional Herb with Modern Therapeutic Relevance. International Journal of Pharmaceutical Chemistry and Analysis. 2025; 12(3): 145–151. doi: 10.18231/j.ijpca.77234.1762763176. DOI: https://doi.org/10.18231/j.ijpca.77234.1762763176